”IgA nephropathy is a common primary glomerular disease and is one of the common diseases that lead to chronic renal failure. Early prevention and early treatment is the key to prevent its transformation into chronic renal failure, and in this issue, let’s learn what is IgA nephropathy.” IgA nephropathy is a common primary primary glomerular disease, characterized by renal immunopathology showing IgA-based immune complex precipitation in the glomerular thylakoid region. IgA nephropathy can occur at any age, with patients aged 15-35 years accounting for 80% of the total number of patients with the disease, and its clinical manifestations are varied, mainly manifesting as hematuria, which can be accompanied by varying degrees of proteinuria, hypertension and impaired renal function, and is It is one of the common kidney diseases leading to chronic renal failure. Now let’s see what are the clinical manifestations of IgA nephropathy Clinical manifestations: IgA nephropathy has a variety of clinical manifestations, which can present the clinical combination of various glomerular diseases, the most common ones are episodic granulomatous hematuria and asymptomatic hematuria or proteinuria. Episodic carnitic hematuria: It is seen in 40%-50% of patients and is transient or recurrent, often occurring a few hours or 1-2 days after upper respiratory tract infection, so it has been called “infectious synchronous hematuria”. Asymptomatic microscopic hematuria with or without proteinuria: About 30-40% of patients show asymptomatic abnormal urinalysis, mostly found during physical examination. Due to the insidious course of the disease, the time of onset is difficult to determine in most patients. The clinical prognosis of this part of patients is mostly good, but not for those with proteinuria, and early kidney biopsy and early diagnosis should be performed in areas with conditions. 3, proteinuria: IgA nephropathy patients mostly show mild proteinuria, 10%-24% of patients with massive proteinuria, and even nephrotic syndrome. 4, hypertension: the incidence of hypertension in adult patients with IgA nephropathy is high, and patients with IgA nephropathy can develop malignant hypertension and is the most important renal parenchymal disease causing malignant hypertension. 5, chronic renal failure: most patients with IgA nephropathy gradually enter the chronic renal failure stage 10-20 years after diagnosis. 6, acute kidney injury. Identifying the disease insights Performing renal puncture and doing renal pathology test is the gold standard for confirming the diagnosis of this disease, but patients still have many concerns in the clinic and are unwilling to accept it. In this case, the initial diagnosis can only be made with reference to clinical manifestations and elevated immunoglobulin A. IgA nephropathy is mainly manifested by recurrent microscopic hematuria or carnivorous hematuria. Some patients have typical “pharyngitis synchronous hematuria” at the initial stage or at the time of recurrence, which has a high diagnostic value in clinical practice. In terms of treatment, Dr. Gao advocates: “Chinese and Western together, Chinese first, then Western”, and hormones plus immunosuppressants can be considered for proteinuria >2 grams or more. In terms of TCM treatment, the new Yi kidney soup created by Master Gao on the basis of his master Yi kidney soup has satisfactory therapeutic effect on this disease!