What are the typical signs and symptoms of prostate cancer?

  In the early stages of prostate cancer, most prostate cancer patients have no obvious symptoms due to tumor limitation, and it is often found by chance during physical examination, or in BPH surgical specimens.  As the tumor progresses, prostate cancer will show many different symptoms, mainly in 3 aspects: 1. Obstructive symptoms: If the cancer of the prostate gland is progressively enlarged and presses the urethra of the prostate gland, the symptoms of prostate cancer may show urinary obstruction, which may manifest as progressive difficulty in urination, frequent urination, urgent urination, painful urination, incomplete urination, etc. In severe cases, urine dripping and urinary retention may occur. These symptoms are similar to those of benign prostatic hyperplasia (BPH), which can easily be misdiagnosed and missed, delaying early diagnosis and early treatment of the disease.  2. Local infiltrative symptoms: When prostate cancer metastasizes to bone, it can cause bone pain at the metastatic site, which is also a common symptom of prostate cancer. Common sites of bone metastasis include spine, hip, ribs and scapula. About 60% of advanced patients experience bone pain, which is commonly found in the lumbar region, sacrum, hip, and hip pelvis. Bone pain can manifest itself in different ways, with some patients experiencing persistent pain and others experiencing intermittent pain. Bone pain can be confined to a specific part of the body or can manifest as wandering pain in different parts of the body; bone pain may change at different times of the day and respond differently to rest and activity.  3.For advanced progressive prostate cancer: the symptoms of prostate cancer may include fatigue, weight loss, and general pain. As the pain seriously affects the diet, sleep and spirit, the whole body condition becomes weaker and weaker after long-term torment, wasting and weakness, progressive anemia, and finally cachexia occurs due to systemic failure.  The classification of prostate cancer: 1.Embedded prostate cancer: It refers to the absence of symptoms and signs of prostate disease before birth. It can occur in any part of the prostate, but it is more common in the central and peripheral areas, and is often a well-differentiated adenocarcinoma. The actual fact is that the development of ambush cancer of the prostate may be related to environmental and genetic factors.  2.Prostate incidental carcinoma: The main clinical symptom is benign prostatic hyperplasia, and prostate cancer is found in the histological inspection of the excised hyperplastic prostate tissue. The histological manifestation is well differentiated adenocarcinoma, mainly tubular adenocarcinoma and sieve-like adenocarcinoma, and a few are low differentiated adenocarcinoma.  3. Occult prostate cancer: The patient has no symptoms and signs of prostate disease, but pathological examination of the specimen in lymph node biopsy or bone puncture confirms prostate cancer. It can be further confirmed by prostate puncture biopsy. Serum prostate-specific antigen and prostate acid phosphatase levels are found in these patients. The biopsy tissue is positive for PSA and PAP immunohistochemical staining.  4. Clinical cancer of the prostate: The clinical diagnosis of prostate cancer can be confirmed by biopsy. The diagnosis can also be assisted by PSA and PAP of patient’s serum. Most of the patients can feel the prostate nodules on anal diagnosis, and ultrasound examination reminds that the prostate nodules have irregular shape, uneven echogenicity and low echogenicity.