Thiazide diuretics, also known as intermediate potency diuretics, are antihypertensive drugs that can be used alone to treat early hypertension, or other antihypertensive drugs in combination to treat moderate to severe hypertension. Side effects mainly include: 1, hypokalemia, is the most common adverse reactions, for prevention can be used intermittent treatment, or combined with potassium retention diuretics, or timely supplementation of potassium salts; 2, there is the possibility of hyperglycemia, long-term use leads to reduced glucose tolerance, increased blood sugar, stopping the drug can be restored; 3, hyperuricemia, for gout patients will aggravate the condition of hyperuricemia; 4, hypercalcemia, thiazide diuretics can promote the reabsorption of calcium thus leading to elevated blood calcium; 5, elevated blood ammonia, patients with serious impairment of liver function, may induce the risk of abnormal liver function; 6, hyperlipidemia, allergic reactions, etc. Finally, please remind everyone to use drugs carefully under the guidance of doctors and pharmacists.