Intermediate thalassemia without complications can be treated without bone marrow transplantation, and for severe beta thalassemia, bone marrow transplantation is the better treatment option. Intermediate thalassemia is divided into alpha thalassemia and beta thalassemia. General treatment, drug treatment, surgical treatment and gene activation treatment can be chosen. 1. General treatment: pay attention to rest and nutrition, actively prevent infection, appropriately supplement folic acid and vitamin E. If the anemia is severe, appropriate amount of red blood cells should be transfused. 2. Drug treatment: Desferrioxamine can increase iron excretion from urine and feces, and the combined application of vitamin C and chelating agent can strengthen the effect of desferrioxamine in iron excretion from urine. 3. Surgery: splenectomy, which is more effective for α-thalassemia and intermediate β-thalassemia, but the resection can lead to immunocompromise, and it should be carried out after the age of 5-6 years old, and the indications should be strictly controlled. 4. Gene activation therapy: the application of chemical drugs can increase γ gene expression or decrease α gene expression to improve the symptoms of β-thalassemia, and the drugs used in clinic are hydroxyurea, cytarabine, etc. The prognosis of thalassemia patients is more different, it is recommended that patients follow the doctor’s instructions to standardize the treatment. The above medications should be used under the guidance of a doctor.