Who are the main culprits of intestinal “depression”? First of all, mental factors, such as environmental noise, work pressure, heavy financial burden, unemployment, death of relatives, interpersonal relationship disorders and family disputes. Neuroticism, agitation, restlessness, anxiety and depression are the character traits of these patients. More than half of the patients are accompanied by phobias, especially cancer phobia. About 33% of the patients have a family genetic predisposition. In addition, the patient is intolerant to one or more kinds of food, which may trigger or aggravate the symptoms after eating. Examples include acidic fruits, spices, alcohol, chili peppers, and strong coffee. Altered gastrointestinal smooth muscle function due to substance abuse can also trigger the disease. Patients should abstain from high-fat foods, alcohol and caffeine in their diet. Eating a balanced and regular diet rich in fiber and starch can reduce the occurrence of symptoms. Now that we have a general understanding of Irritable Bowel Syndrome, the diagnosis of this woman suffering from diarrhea is clear. It makes sense that her introverted and suspicious personality and the misfortunes she has encountered in her life would lead to intestinal depression. It is recommended that patients with chronic abdominal pain and diarrhea should consult gastroenterologists and clinical psychologists when the cause of their condition is not detected by colonoscopy, in order to make a reasonable diagnosis and treatment as early as possible. Irritable Bowel Syndrome (IBS): 1. 70% of the patients have mild or occasional symptoms, and can maintain normal life and work. 2. 25% are medium-sized with typical clinical symptoms, periodic onset, often with triggering factors and heavy psychological burden, abdominal pain can be up to several years, abdominal pain is spasmodic, with a short period of severe pain. Diarrhea or constipation, feces in the form of paste or loose stools, with a large amount of mucus, several times a day, often occurring in the morning or the night after, the patient may also be accompanied by abdominal distension, dyspepsia, insomnia, palpitations, sweaty hands and feet, head and face fever and other symptoms. 3, 5% for heavy light and lightweight of the above symptoms, but all have severe, frequent pain unrelated to diet, activity or physiological changes, accompanied by psychological disorders such as anxiety, depression and somatization of symptoms. The intestine has been called the ‘second brain’: the enteric plexus is spread throughout the intestinal wall from the mucosa to the plasma membrane, and is connected to the central nervous system (brain) via nerve fibers and nerve mediators, which, on the one hand, enable sensory information to reach the brain, and on the other hand, allow the activity of the intestine to be centrally regulated. In recent years, it has been confirmed that the neuromediators associated with the enteric plexus: 5-hydroxytryptamine, substance P, endorphins, etc. are also found in the central nervous system.