A sore throat may be due to the presence of inflammatory reaction in the throat and tonsils, when the own resistance is low. Vaccination may lead to aggravation of the inflammatory reaction, which may not stimulate the body to produce the corresponding protective antibodies, so that the vaccine cannot play its protective and preventive role well. However, because of the variety of vaccines, vaccination at the time of sore throat may also have no effect on the effect of vaccines: i. aggravation: vaccines are foreign substances to the human body, and most of the vaccines are inactivated vaccines. When vaccinated during the period of throat inflammation, it may aggravate the pain in the throat and even aggravate the symptoms of inflammation, causing bronchitis, tracheitis, and even pneumonia and other respiratory diseases. Patients may experience coughing, coughing up phlegm, difficulty in breathing, fever, etc., making it more difficult to treat and recover from colds. Second, cause adverse reactions: 1. local symptoms: redness, swelling, pain, soreness and hard knots at the inoculation site; 2. systemic symptoms: malaise, fever, myalgia, headache, etc. may occur, and allergic reactions, even anaphylaxis, may also occur; 3. digestive system symptoms: nausea, vomiting, loss of appetite, etc. may occur to varying degrees. In addition, patients are advised to clarify the cause of sore throat and treat it symptomatically, and vaccination may be suspended. In crowded environment, pay attention to self-protection, daily rest and drink more water to promote early recovery of the throat, and vaccination can be given only after healing.