Numbness and weakness of the hands and feet should be registered with the Department of Neurology, depending on the specific clinical manifestations of the patient and the site of involvement. If the numbness and weakness of the lateral limbs is considered to be a central injury, the most common is cerebrovascular disease with acute onset, especially in elderly patients with hypertension, diabetes, hyperlipidemia and other underlying diseases, sudden onset of numbness and weakness of the lateral limbs may be cerebral infarction or cerebral hemorrhage, improve the head CT, MRI examination can help confirm the diagnosis. In case of numbness and weakness in all four limbs at the same time, patients with acute onset should consider Green-Barre syndrome, which is an acute inflammatory disease of peripheral nerves and nerve roots in the limbs induced by infection, and in severe cases, it can involve respiratory muscles and lead to respiratory paralysis. If the disease is chronic, multiple peripheral neuropathies or metabolic peripheral neuropathies should be considered, and the cause of the disease should be clarified by examining the nerve conduction velocity of the extremities, blood glucose, blood lipids, liver and kidney functions, tumor indicators, and rheumatologic and immunologic inflammatory indicators.