Sudden numbness and weakness in the hands and feet should be considered to be caused by acute cerebrovascular disease if the limbs are on the lateral side. For example, due to brain hemorrhage or cerebral infarction, the patient’s motor nerves and sensory nerves are damaged, and the patient will show the symptoms of numbness and weakness in hands and feet. Patients who have no strength in the limbs of the hands and feet, as well as symptoms of tingling, should first consider problems in the spinal cord, such as acute myelitis, which can lead to weakness in the limbs and numbness in the hands and feet. Secondly, myasthenia gravis should be considered. Patients may have symmetrical and delayed muscle weakness in the limbs, which usually develops gradually from the distal to the proximal end. Patients may experience morning lightness and evening heaviness, with symptoms being relatively mild in the morning and increasing in the evening. In severe cases, patients may experience incontinence or respiratory failure.