The main thing to reduce fever when you have a high fever is to apply anti-inflammatory drugs that relieve fever and analgesia, starting with drugs such as ibuprofen. If nausea and vomiting are present and you cannot eat, you can administer the medication through the rectum, that is, with indomethacin suppositories or suppositories of acetaminophen. High fever is mainly reduced by this method. When available, physical cooling can also be tried, usually by dipping the patient’s forehead and armpits in warm water to promote heat dissipation, and by evaporating the water dipped in wetness on the skin surface, heat is taken away, thus controlling the body temperature. Glucocorticoids can also be used appropriately if there is recurrent high fever and a more pronounced inflammatory response. For people with recurrent fever and a relatively heavy associated inflammatory response, appropriate application of glucocorticoids generally does not cause significant side effects and is more beneficial for controlling the condition. To control the temperature quickly, it is also more important to carry out cause-specific treatment. If the sepsis is caused by a bacterial infection, antibiotics should be applied promptly, otherwise the corresponding fever is likely to not go down or to rise repeatedly. If it is a more specific virus, you can also try to treat it with antiviral drugs.