The 21st century environment is the most diabetes-prone environment ever seen in human history, with the incidence of type 2 diabetes increasing approximately 1-fold in the United States and 3-5-fold in India, Indonesia, China, Korea, and Thailand over the past 25 years. Diabetes is the only 2nd disease to receive such high priority from the United Nations after AIDS. Diabetes is now seen as a major global public health problem, particularly unaffordable for developing countries. For both developed and developing countries, diabetes is currently the leading cause of end-stage renal failure. How to prevent and treat diabetic nephropathy in the following steps: 1. Change poor lifestyle to prevent diabetes and nephropathy 2. Early detection of diabetic nephropathy, screening for albuminuria and decreased kidney function. 3.Civic education for diabetic nephropathy in the community, so that people understand that diabetes is a risk factor for kidney disease. 4.Application of ACEI or ARB drugs is the standardized treatment for diabetic nephropathy. 5.Waiting for the development of new treatments for clinical application Management of diabetic nephropathy: Fortunately for early stage patients, early therapeutic interventions can delay the onset of complications and improve the prognosis. We see many men in their 40s and 50s in the clinic, with high blood glucose and blood pressure for several years, not caring, some taking some medication, and not knowing how well it works, and continuing to spend 5 nights a week at the drinking table, and then one day finding that their lower limbs are a little swollen, and not knowing when to drag them to the hospital. After arriving at the hospital, it was found to have kidney failure.