Chemotherapy for patients with large cell lung cancer usually lasts for 21 days, and a few patients with poor physical condition may need 28 days for chemotherapy. Lung large cell carcinoma belongs to a kind of non-small cell lung cancer, and according to the different purposes of chemotherapy for patients, the clinic mainly divides it into three types of chemotherapy, such as preoperative neoadjuvant, postoperative adjuvant and late-stage palliative, and the commonly used medicines include paclitaxel, gemcitabine, cisplatin, carboplatin and so on. Most of the above chemotherapy adopts three-week chemotherapy regimen, and a few adopt four-week regimen. Generally, neoadjuvant chemotherapy and late palliative chemotherapy, most of them assess the efficacy after two cycles of chemotherapy, and during the period of chemotherapy, weekly testing of blood routine, liver and renal function and other indicators, and close observation of gastrointestinal reaction and other side effects, so as to deal with them in a timely manner.