TRUST is a toluidineredunheatedserumtest, which is a non-specific serologic test for syphilis spirochetes like RPR. The difference between the two is that RPR uses a special charcoal powder as the display agent, while TRUST uses toluidine red as the display agent, and the latter has a better detection rate and reproducibility than the former. In terms of diagnosis, because of the high sensitivity and low specificity of the non-specific syphilis spirochete antigen serology test, the diagnosis of syphilis needs to be combined with the specific syphilis spirochete antigen serology test, such as TPHA, TPPA, etc. In terms of treatment, the TRUST titer is related to the activity of syphilis and is a common indicator for clinical evaluation of syphilis treatment, and is one titer higher than the RPR method of potency determination. After regular syphilis treatment, a decrease in serum TRUST titer or even a change from positive to negative indicates that the treatment is effective, but it is still necessary to review regularly and follow up for 2~3 years to avoid recurrence and reinfection. False-negative TRUST reactions, like false-negative RPR reactions, are common in patients with stage I syphilis (less than 2-3 weeks of infection) and should be repeated after 4 weeks in suspected patients. other reasons.