In the middle of the night urinary tract infection, can not sleep, it is recommended that you should drink more water, urinate more, see if there are anti-inflammatory drugs at home, you can eat levofloxacin, ciprofloxacin, moxifloxacin, erythromycin, roxithromycin, doxycycline, clarithromycin, cefdinir, cefaclor, etc.. These drugs are broad-spectrum antimicrobials with high concentration in the urinary tract and good effect. The vast majority of urinary tract infections are caused by Escherichia coli, and these drugs have a good effect on Escherichia coli. You can appropriately wash the perineum, and the symptoms of frequent urination will improve, and you can also take warm water sitz baths and apply hot compresses to the bladder area to relieve symptoms such as urinary urgency and pain. It is recommended to have a routine urine test the next day to assess the severity of the inflammation and then decide how to proceed with further treatment.