Parkinson’s disease (PD), also known as tremor paralysis, is a common neurodegenerative disease of middle-aged and elderly people. Although it is not fatal, symptoms such as tremor paralysis, mobility difficulties, mental depression and other symptoms will affect the patient’s work and life, and the condition is getting more and more serious over time, and the effect of drug treatment is getting worse and worse. For the “old Palmers” in the drug treatment of clinical pathway encountered many problems, simply taking drugs has been difficult to control the condition, but also need surgery, rehabilitation training multi-pronged approach. “Old Parkinson’s friends” suffer a lot As we all know, Parkinson’s disease diagnosis and treatment guidelines mentioned that the first choice of treatment is drug treatment, but for more than 5 years of “old Parkinson’s friends”, drug treatment has a “honeymoon period However, for “old pals” with more than 5 years of experience, there is a “honeymoon period” for medication, after which the effect of the medication will get worse and worse, or even the effect of the medication will only last for 1-2 hours per dose. And there are end-of-dose phenomenon, switch phenomenon and anisotropy and other manifestations. And taking medication for a long time will produce side effects, and have some damage to the body organs and brain. All this makes the “old Palmers” suffer a lot. After the honeymoon period of medication, surgery can be considered after about five years. On the one hand, surgery can reduce or eliminate the symptoms of Parkinson’s disease and reduce the amount of medication; on the other hand, it can improve the side effects and complications caused by medication. Surgery can be considered for patients who have had the disease for 3-5 years. Older patients with Parkinson’s disease can be considered for surgery as soon as possible in the following two situations. First of all, for patients who have been ill for 3-5 years, due to the development of the disease, the side effects caused by long-term medication; the efficacy of the medication is getting worse and worse, and the motor symptoms still affect the daily life and work after taking anti-Parkinson’s disease medication. Early surgical treatment at this time can significantly improve the quality of life of patients. Second, the patient suddenly appeared “switch phenomenon”. This is a phenomenon in which a patient with Parkinson’s disease suddenly experiences worsening symptoms, generalized stiffness, and difficulty in walking, but without any treatment, the symptoms suddenly disappear after a few minutes. The “on-off phenomenon” can occur at any time and in any state of the patient’s life schedule, regardless of the time and dosage of the medication. Surgery is the best treatment for patients with moderate to advanced Parkinson’s disease. There are currently two types of surgical treatment for Parkinson’s disease, Stereotactic Sub-Nucleus Modulation and Deep Brain Stimulation. Surgery to improve symptoms has many benefits The indications for the two types of Parkinson’s disease surgery are different, with clear advantages and disadvantages. Destructive surgery is mainly applicable to patients with unilateral symptoms, and the treatment can lead to irreversible destruction of the neuronal nuclei, which is relatively economical in terms of medical expenses; deep brain stimulation is mainly applicable to patients with bilateral symptoms, and also uses minimally invasive techniques, which can be reversible and debugged, and is relatively expensive in terms of medical expenses. Through surgical treatment, most patients’ symptoms can be significantly improved, tremor, bradykinesia, stiffness, limb pain, etc. are relieved, and the patient’s mood will improve after the operation, and sleep will also improve, which can also promote the better performance of medication, and the quality of life is significantly improved. Patients and their families should have a full understanding of Parkinson’s disease and its treatment options, through internal medicine, surgical stereotactic surgery and other means can only significantly improve the symptoms, improve the quality of life, but can not cure Parkinson’s disease. Patients should insist on long-term outpatient follow-up and receive rehabilitation exercises.