Positive anti-beta2-glycoprotein 1 antibody is one of the antibodies associated with antiphospholipid syndrome, an autoimmune disorder in pregnant women. The diagnosis of antiphospholipid syndrome is made by a history of two or more early miscarriages or one or more preterm deliveries combined with positive antibodies, including anticardiolipin antibodies, anti-beta2-glycoprotein 1 antibodies, and lupus anticoagulants. If the diagnosis of antiphospholipid syndrome is made, heparin as well as aspirin anticoagulation needs to be given to benefit the next pregnancy.