Treatment principles Surgery should be preferred for the localized type, while surgery and chemotherapy can be combined for the diffuse type. Medication principles 1. Pain relief for those with chest pain. 2.Pemetrexed + cisplatin-based chemotherapy regimen can prolong survival. 3, γ-interferon, interleukin as adjuvant treatment measures. 4.Pleural adhesions such as talc and tetracycline can be used for those with more pleural fluid. There is still no effective radical cure. In terms of treatment, there are palliative treatment, surgical treatment, chemotherapy and radiation therapy, etc. It is generally believed that for stage I patients with relatively limited tumor, radical pleuropneumonectomy is advocated. For stage II, III and IV patients, radical surgery is no longer meaningful and only palliative surgery can be performed. In fact, most patients are already in stage II or higher by the time the disease is definitively diagnosed. The rapidly growing pleural fluid often leads to severe respiratory distress, so palliative surgery is important to improve the quality of life of these advanced patients. The use of thoracoscopic pleural fixation has shown good results in the palliative treatment of malignant pleural mesothelioma.