Epithelioid malignant pleural mesothelioma is a malignant tumor originated from pleura, which requires standard treatment under the guidance of clinicians, and the main treatment options include surgical resection, radiotherapy and daily care. 1. Surgical resection: if the scope of lesion is relatively small, simple pleural tumor resection can be done; if the scope of lesion is large and causes obvious invasion to adjacent lung tissues, total resection of pleura and lung tissues is needed. 2. Radiotherapy: postoperative radiotherapy is needed to control the disease through adjuvant radiotherapy, and the commonly used chemotherapeutic drugs in clinic include pemetrexed, etc. Radiotherapy has a deviated effect in overall view, and is mainly used for controlling pleural effusion and preventing recurrence of the tumor, and it can be used to expand radiotherapy of the chest wall. 3. Daily care: usually pay attention to avoid excessive exposure to dust and cold air, pay attention to adjust the diet, with nutrition, pay attention to replenish protein, pay attention to ensure sufficient rest. Epithelioid malignant pleural mesothelioma, causing peripheral obvious invasion as well as destruction, causing chest pain, need to consult a doctor in time for observation and standardized treatment under the guidance of clinicians.