Pleural mesothelioma is a tumor originated from pleural mesothelial cells, which is the most common primary tumor of the pleura, and the more commonly used surgical methods are expanded pleuropneumonectomy and pleurectomy. 1. Expanded pleuropneumonectomy: this surgery is only applicable to patients with stage I functional epithelial malignant pleural mesothelioma. 2. Partial pleuropneumonectomy: It cannot achieve the goal of cure, but it can reduce the symptoms of patients, especially for patients with ineffective chemical pleural fixation and pulmonary atelectasis syndrome. Patients with pleural mesothelioma should go to the hospital for examination in time and be treated under the guidance of doctors. For tumors that cannot be surgically removed, the treatment advocates the use of drug therapy, and the chemotherapeutic drugs commonly used in clinical practice include pemetrexed and cisplatin or carboplatin. Drugs need to be used under doctor’s guidance, avoid self-medication.