Pleural mesothelioma requires different treatments according to its different stages, as follows: 1. early stage: if there is an opportunity for surgical operation, i.e., pleurodesis is performed; 2. middle and late stage: the opportunity for surgical treatment has been lost, at this time, drug therapy is the main treatment, i.e., chemotherapy is used to reduce the symptoms and prolong the survival of patients. At present, the data of targeted drugs and immune drugs are not ideal, but some targeted drugs have some therapeutic effect on the disease. Therefore, it is recommended that patients should seek treatment in a timely manner when discomfort occurs, and early detection and treatment usually have a relatively good prognosis.