The correlation between allergic diseases and malignant tumors has always been a concern and is controversial. Some experts believe that allergic people have a stronger immune system, which reduces the incidence of tumor diseases represented by immune deficiency; some other experts believe that allergic people are easily provoked by internal and external stimuli and “go astray”, which leads to mutations and malignant tumors. Dr. Jinfeng Xiang from the Department of Pancreatic Surgery, Fudan University Pancreatic Tumor Research Institute / Fudan University Cancer Hospital, reported on the correlation between allergic diseases and the risk of pancreatic cancer in patients, taking into account the latest literature. To date, pancreatic cancer is still a malignant solid tumor that needs to be studied. There is still a lack of clear understanding of the etiology of pancreatic cancer and the associated causative factors (environmental, genetic, etc.). Existing studies have pointed to an important role of chronic inflammation in pancreatic carcinogenesis, and some recent studies have shown a negative association between allergic rhinitis and pancreatic cancer prevalence. However, the relationship between some other allergic diseases such as asthma and pancreatic cancer is still controversial. In the December 2015 issue of GUT, an article entitled “Reduced risk of pancreatic cancer associated with asthma and nasal allergies” was published, examining the association between asthma and allergic rhinitis and the risk of pancreatic cancer. One of the highlights of this study is that it actually combines two analyses. In the first part, the authors obtained 2300 eligible questionnaires containing 18 allergy-related items (Table 1) based on an international multicenter study PanGenEU (containing 2000 cases and 2000 controls, 2009-2014) initiated in 6 European countries (UK, Germany, Ireland, Italy, Spain, Sweden). The analysis revealed that: 1. allergic rhinitis was significantly negatively associated with the risk of pancreatic cancer (OR 0.66 95% CI 0.52-0.83); in particular, patients who developed specific allergic rhinitis symptoms within one year of enrollment had a more significant negative association (OR 0.59, 95% CI 0.46 to 0.77), while those who developed allergy more than one year from enrollment were not associated with the risk of pancreatic cancer (OR 1.09 95% CI 0.76 to 1.59); 2. asthma was also negatively associated with the risk of pancreatic cancer The risk of pancreatic cancer was also negatively associated with asthma (OR 0.64, 95% CI 0.47 to 0.88); in particular, patients who had the disease for more than 17 years had the lowest risk of pancreatic cancer (OR 0.39, 95% CI 0.24 to 0.65); those who were currently taking anti-allergy medication had a lower risk of pancreatic cancer (OR 0.47, 95% CI 0.31 to 0.69); and those with higher athma severity scores also had a lower risk of pancreatic cancer. In the second part of the study, the authors further confirmed their findings by conducting a META analysis, which also supported the findings of the previous part: 1) asthma was negatively associated with the risk of pancreatic cancer (metaOR 0.73, 95% CI 0.59 to 0.89); 2) allergic rhinitis and skin allergy were also negatively associated with pancreatic cancer (metaOR 0.6, 95% CI 0.5 C 0.72, and metaOR 0.77, 95% CI 0.64 to C0.93). Important conclusion: pancreatic cancer has a significant negative correlation with allergic rhinitis, asthma, and allergic diseases are likely to be effective in reducing the risk of cancer development! At the same time, the authors also point out that although this study does not explore and explain the underlying mechanisms, it is a good reminder for future studies that immune status is much more profoundly related to cancer risk and disease development and progression than we know now, and the clinical translation and application of related studies are also of far-reaching significance!