Hepatitis B triple yang into big two yang is not a self-cure, only the hepatitis B virus carrier status has changed, we recommend that patients continue to receive treatment under the guidance of the doctor. Hepatitis B triple positive refers to the surface antigen, e antigen and core antibody positive, big two positive refers to the surface antigen and e antigen positive, Hepatitis B triple positive into big two positive is just a change in the state of hepatitis B virus carries, can not be used as a basis for diagnosis. Whether the condition has improved after hepatitis B triple yang has turned into big two yang should be determined according to the indicators of liver function and the amount of hepatitis B virus carried, if the liver function recovers after hepatitis B triple yang has turned into big two yang and the amount of hepatitis B virus carried decreases, it indicates that the condition has improved. Hepatitis B triple yang into big two yang is not a self-cure, need to be determined by liver function, hepatitis B virus carriers and other indicators to determine whether or not the condition has improved, it is recommended to continue to receive treatment under the guidance of the doctor.