The hand rubbing-like movement is one of the clinical manifestations of Parkinson’s syndrome. It is a degenerative disease of the substantia nigra and substantia nigra striata pathways that occurs in adults over middle age. 10% of patients have a family history; some patients may have similar manifestations due to encephalitis, cerebral arteriosclerosis, and traumatic brain injury. Below, we learn about the causes of the pill-rubbing-like movements of the hands. The cause of Parkinson’s disease is not well understood. It is now recognized that the cause is degeneration of nerve cells, with the main lesions in the substantia nigra and striatum. The gradual decrease in the number of nigrostriatal cells and the gradual loss of their function leads to a decrease in a substance called dopamine, which causes the above symptoms. According to the results of animal experiments and epidemiology, Parkinson’s disease also has a genetic relationship. According to the cause, tremor paralysis symptoms can be divided into two categories, one is called primary tremor paralysis, that is, no clear cause can be found or the cause may be related to genetics, we will call it Parkinson’s disease or Parkinson’s disease. The other category is called secondary tremor palsy, which is caused by some kind of encephalitis, poisoning (such as carbon monoxide, manganese, cyanide, reserpine poisoning, phenothiazines and butylphtalazine and tricyclic antidepressants, etc.), cerebrovascular disease, cranial injury, brain tumor, etc., we also call it Parkinson’s syndrome or Parkinson’s syndrome, tremor palsy syndrome.