The middle-aged and elderly want to be healthy, but as we age, the chances of some diseases increase, such as multiple myeloma. Multiple myeloma occurs in middle-aged and elderly people over 60 years of age. The disease does not produce clinical symptoms in a short period of time, but usually worsens gradually with no obvious symptoms, and most of the patients are found to have unexplained pain, especially lower back pain or unexplained fractures. The current incidence rate is 1-4/100,000, accounting for 6% of malignant tumors, and is increasing year by year, second only to lymphoma and higher than leukemia. Multiple myeloma is a malignant tumor caused by abnormal proliferation of plasma cells in the bone marrow. Due to a large number of abnormal plasma cells proliferating in the bone marrow, causing osteolytic destruction, and due to a large number of abnormal monoclonal immunoglobulins in the serum and Benzo’s protein in the urine, causing damage to kidney function, anemia and abnormal immune function, it is very easy to contract fever. The four most important symptoms include hypercalcemia, renal failure, anemia, and skeletal destruction lesions. Among them, skeletal pain sometimes causes the patient to have difficulty walking, with painful manifestations in the vertebrae, ribs, and thoracic spine being the most common. More than 2/3 of patients will have skeletal pain at the time of diagnosis, and about 80% of patients will have skeletal dysfunction. Chemotherapy is the main treatment modality for multiple myeloma, but because myeloma cells can easily develop drug resistance, myeloma treatment is ineffective, with an average survival of 3-5 years. The widespread use of new therapies has brought significant survival benefits for patients with multiple myeloma after first relapse and multiple relapses.