New Crown vaccine is not recommended for large lymph nodes. The causes of lymph node enlargement are complex, there may be inflammatory infections or systemic diseases, such as malignant tumors, lymphoblastic leukemia, and lymphoma, etc., all of which can cause lymph node enlargement, and if the patient’s condition is in the active stage, it is not recommended to give the vaccine. If the patient’s condition is active, it is not recommended to take the vaccine. Taking the vaccine during an exacerbation of the disease may aggravate the discomfort of the patient’s body, especially if the patient is taking medication or undergoing radiotherapy, which may also have a reciprocal effect on the vaccine, so it is recommended to take the vaccine after the patient’s condition has stabilized. If the patient has fever or serious chronic diseases, he/she should consult a doctor in advance before taking the vaccine in order to avoid any adverse effects.