Serious symptoms of hepatitis B vary from person to person. When hepatitis B is severe, symptoms such as fatigue, abdominal distension, spider moles and enlarged spleen may occur. If not actively controlled, it may also develop into decompensated cirrhosis or hepatocellular carcinoma, which may lead to severe liver function impairment. When hepatitis B is severe, there will be persistent manifestations of hepatitis, such as fatigue, bloating and loss of appetite. Some people may also have a dark, lifeless face and congestion between the palms of the hands and the margins of the fishes. A few people may feel swelling under the left rib cage. Progressing to the decompensated stage, the main presentations are dysphoria, jaundice, diarrhea, and portal hypertension. Once entering the decompensated stage, it means that the disease can no longer be reversed, and scientific treatment is also needed to address the specific causes and improve one’s quality of life. When the disease develops into hepatocellular carcinoma, gastrointestinal symptoms, such as nausea and vomiting, will often appear, and as the disease continues to develop, there will be pain in the area of the liver, accompanied by enlargement of the spleen, lethargy and fever, and other manifestations. Hepatitis B should be treated as soon as possible to help minimize the impact on one’s health and life.