Taking hormones may lead to centripetal obesity, which usually gradually decreases within 3-5 years after stopping the medication. The main reason for taking hormones to cause centripetal obesity is that hormones can increase appetite, and the patient’s intake of high-fat and high-calorie food increases due to hyperphagia, and calorie intake is greater than calorie consumption, and hormones can redistribute fat, reduce fat and muscle in the extremities, and increase fat in the abdominal back and face, forming central obesity. Usually, obesity can be gradually reduced within 3-5 years after stopping the use of hormones. If patients use hormones frequently or suffer from liver disease or kidney disease, which cause edematous changes, the duration of obesity will be relatively longer, and in serious cases, it may not subside for life. Patients should restrict high-fat and high-calorie foods while taking hormones, and choose low-calorie foods such as vegetables and fruits. It is advisable to have small and frequent meals, monitor blood sugar, and exercise appropriately. At the same time, patients should pay attention to the use of hormones under the guidance of doctors and avoid blindly stopping or increasing the dosage.