Indicators reflecting the critical condition of patients in shock are the following: first, intractable hypotension, especially if the patient is not dehydrated and has adequate blood volume, the patient’s systolic blood pressure is continuously below 90 mmHg and must rely on larger doses of vasoactive drugs, such as dopamine, to maintain the systolic blood pressure above 80 mmHg. Second, changes in mental status, which may manifest as excitement in the early stage and gradually change to depression and coma in the late stage. Third, intractable hypoxemia, which cannot be corrected by nasal catheter and mask oxygenation and requires the application of ventilator-assisted breathing. Fourth, multi-organ failure, acute renal failure can be manifested as anuria, oliguria and progressive hyperkalemia, acute liver failure can be manifested as increased odds of transaminases, jaundice, and myocardial damage can be manifested as increased cardiac enzymes.