Pustules on the soles of the feet require careful observation of the appearance and shape of the pustules. They are most commonly caused by bacterial infections, followed by diseases such as palmoplantar impetigo and aspergillosis. If the pustules are isolated, red in appearance and accompanied by obvious pain, it is considered to be related to factors such as friction and irritation. Prolonged walking or strenuous exercise, or shoes that are too narrow, can lead to excessive friction on the soles of the feet resulting in blisters, which can easily become infected and form pustules without timely disinfection treatment. In addition, foot lesions such as tinea pedis and eczema that appear as blisters can also be transformed into pustules if secondary bacterial infections occur. Bacterial infections are usually treated on the basis of the primary disease, surgical incision and drainage, postoperative application of antibiotics to treat the infection, and the usual need to try to avoid factors that cause excessive friction, while paying attention to personal cleanliness. If the local pustules appear to be densely arranged and obvious red flakes can be seen between the pustules, it may be palmoplantar pustulosis, which mainly occurs on both sides of the soles of the feet and may be accompanied by slight itching or no pain or itching. This disease requires long-term continuous treatment, and it is recommended to follow medical advice after diagnosis. If the pustules are widely distributed and the skin is thin and easily broken, it may be a connective tissue disease such as aspergillosis or aspergillosis-like disease, which requires pathological examination in hospital and systemic systemic treatment after a clear diagnosis.