Pemphigus is a life-threatening autoimmune skin disease. Antibodies to aspergillosis in the patient’s serum attack their own skin mucosa, causing highly ruptured, loose blisters and vesicles on normal skin or mucous membranes. In 2004, the American Academy of Dermatology found that the mortality rate of aspergillosis was 23.9 percent. Since 2000, the Department of Dermatology at Ruijin Hospital has used an “individualized” treatment plan, with as little glucocorticoid therapy as possible, without a single case of serious complications, and the mortality rate of aspergillosis is zero. The problems in the treatment of patients with pemphigus are: some patients fail to diagnose and treat the disease at an early stage, which delays the disease; some patients stop the medication prematurely after the symptoms are controlled, which leads to more serious relapse of the disease or the use of excessive doses of glucocorticoids, which causes complications. Therefore, under the guidance of a specialist physician, adhering to regular and reasonable treatment can completely control the disease within a certain period of time, and even complete recovery. Patients should pay attention to: 1. Stay optimistic, build up confidence, cooperate with the treatment and care of medical personnel; learn to self-protect and care for the erosion surface of the skin and mucous membrane. 2, glucocorticosteroids are still effective, low-cost drugs for the treatment of the disease, treat its side effects correctly, under the guidance of a specialist physician reasonable application, do not increase or decrease the dosage or discontinue the drug on their own. Of course, you should not over-treat and increase its side effects. 3, when there is oral erosion should be diligent rinse mouth, keep the mouth clean, if necessary local drug treatment; choose soft food or semi-liquid food, the temperature should be cool, avoid eating spicy stimulating food. When you have vulva and perianal erosion, you should also keep your local area clean and strengthen your care and treatment. 4. Sleep in the healthy side position to avoid pressure on the affected area; if there are blisters and erosions on the skin around the body, you should change your position more often and do not lie in a fixed position; cut your nails short and wear loose and soft cotton clothes and pants. 5. Patients with aspergillosis are prone to hypoproteinemia, so choose a diet of easily digestible high-protein foods to facilitate the healing of the vesicles and the regression of the blisters. 6. It is best to perform blood pressure and blood glucose tests on your own. 7.Regular outpatient follow-up to test the antibody titer and antibody subtype of aspergillosis and adjust the dosage and type of medication.