Erythrodermic aspergillosis is a chronic, relapsing, severe, intraepidermal acantholytic maculopapular skin disease. The etiology of the disease is not fully understood and is now considered to be an autoimmune systemic disease. The main treatment is a combination of glucocorticoids and other treatment options. The treatment options are: I. General treatment, general treatment is to give a high-protein diet, multivitamin supplementation, pay attention to the water-electrolyte balance, fasting people should be intravenous nutrition, systemic failure can be repeated small amounts of blood or plasma transfusion. It is necessary to strengthen the care, pay attention to the cleanliness and hygiene of the skin, and reduce the secondary infection of the traumatic surface. Second, in terms of systemic therapy, glucocorticoid is a very key drug and is the drug of choice for the treatment of this disease. Try to achieve timely and adequate dosage, correct reduction and maintenance with small doses. It is also necessary to see if immunosuppressants are needed according to the specific condition. For localized to be treated, pay attention to oral hygiene.