Pemphigus is a chronic recurrent disease characterized by the formation of large intraepidermal blisters. The body produces autoantibodies against the interstitial matrix of compound squamous cells (i.e., pemphigus antibodies), which activate certain protein hydrolases in the epidermal cells by binding to the corresponding antigens, causing the epidermal cell adhesions to dissolve and leading to basal loosening. There are four clinical types of pemphigus: the common type, the proliferative type, the deciduous type, and the erythematous type. The symptoms of different types of pemphigus are different, as follows: 1. Common type of pemphigus (1) Oral cavity: The lesions appear earlier. There is often a dry mouth, dry throat or stinging pain when gulping, 1-2 or widespread blisters of varying sizes, with thin and transparent walls, easily broken blisters and irregular vesicles; residual blister walls remain and recede in all directions. The lesions may appear on the soft palate, hard palate, parapharynx, and any other area susceptible to friction, and the blisters may precede or occur simultaneously with the skin. Patients have difficulty chewing, swallowing and even speaking, non-specific halitosis, enlarged lymph nodes, and increased saliva with blood. (2) Skin: The lesions mostly occur on the forehead, trunk, scalp, neck, armpits, groin and other places susceptible to friction. In the early stage, there are only 1-2 blisters on the forehead or trunk, which often go unnoticed. Blisters of different sizes often appear suddenly on normal skin, they do not fuse, their walls are thin and loose and easily broken, and after breaking they reveal a red and wet vesicular surface, which can become pus after infection and form a pus and blood scab with a foul odor, which later heals and leaves a deeper pigmentation. The blisters can be formed rapidly by gently pushing the normal skin or mucous membrane with fingers, or the original blisters can be moved on the skin. (3) The same lesions as those of the oral mucosa can occur in the mucous membranes of the nose, eyes, external genitalia, anus, etc., and are often not easily restored to normal. 2. Proliferative aspergillosis (1) Oral cavity: the same as the common type, except that there is often significant proliferation in the red line of the lips. (2) Skin: Large blisters are commonly found in the folds of the axilla, umbilicus, and perianal area, with positive Ney’s sign. Papillary proliferation occurs at the base of the blister after it breaks, and it is covered with a thick yellow crust and exudate with a fishy odor and self-induced pain. A narrow red halo surrounds it. The blisters may fuse and are variable in extent, and secondary infection is associated with high fever. Patients gradually weaken and often die from secondary infections. (3) The same damage can occur in the nasal cavity, labia, glans, etc. (3) Deciduous aspergillosis (1) Oral cavity: The mucosa is completely normal or slightly red and swollen, and there may be superficial erosions. (2) Skin: manifests as loose blisters with yellowish-brown scaly scabs after the blisters break, and the edges are raised in a leafy shape. (3) The conjunctiva and vulvar mucosa are also frequently involved. (4) Erythrodermic aspergillosis (1) Oral cavity: mucosal damage is less common. (2) Skin: symmetrical erythema and scaly scabs on the face. Through the above introduction, we should understand the classification of the symptoms of aspergillosis. We need to remind patients that although the symptoms of aspergillosis are diverse, the clinical treatment is mostly hormonal, and the difference lies mostly in the amount of dose, so it is often difficult to cure completely. This is mainly because general hospitals do not have a systematic treatment plan and can only use hormones to inhibit the development of the disease.