Blood creatinine 125μmol/L is usually abnormal and mildly elevated. It may be caused by physiological reasons such as higher muscle content or eating more meat in general, or it may be caused by pathological reasons such as acute kidney injury or chronic renal insufficiency. Normal serum creatinine ranges from 53 to 106 μmol/L in men and from 44 to 97 μmol/L in women. Therefore, blood creatinine of 125 μmol/L is not normal and is mildly elevated. Some patients with elevated creatinine may be caused by their own high muscle content, or eating more meat and exercising more in general. If there is no abnormality in urine routine and urinary system ultrasound and other related examinations, creatinine may return to normal after adjusting lifestyle. If patients have acute kidney injury due to various reasons, creatinine may return to normal after correcting reversible causes; if chronic renal insufficiency leads to creatinine elevation is usually irreversible, need to actively treat the primary disease, delay the progressive deterioration of renal function, creatinine usually can not return to normal. If patients find that the creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.