Whether hepatitis B surface antigen 0.553 need to take antiviral drugs can not be generalized, but for pregnant women, receiving radiotherapy and close relatives suffering from hepatitis B cirrhosis or liver cancer, it is recommended to take antiviral drugs. Hepatitis B surface antigen 0.553 indicates that the patient is a hepatitis B carrier, most patients do not need antiviral treatment, so there is no need to take antiviral drugs, usually to ensure a reasonable diet, develop good habits, appropriate exercise, and appropriate psychological counseling can be. However, for pregnant women carrying hepatitis B virus, it is easy to transmit the virus to their children, so patients need to take antiviral drugs in the 24th to 28th week of pregnancy to avoid mother-to-child transmission. For hepatitis B carriers undergoing radiotherapy or immunosuppressant treatment, they also need to take antiviral drugs at the same time, such as entecavir, tenofovir and so on. If the patient’s serum is positive for hepatitis B virus, it means that the risk of the disease is higher, and for patients with a family history of cirrhosis or hepatocellular carcinoma, they also need to take antiviral drugs for treatment. It is recommended that patients presenting with hepatitis B surface antigen 0.553 take reasonable treatment measures strictly under the evaluation of a doctor.