The Department of Vascular Surgery of the First Hospital of Fujian Medical University has successfully carried out autologous peripheral blood stem cell transplantation for the treatment of diabetic foot, based on the successful treatment of lower limb thrombo-occlusive vasculitis with stem cell transplantation, and recently gave a new life to an elderly woman who had been suffering from the disease for 8 years. The patient was diagnosed with diabetic foot, with cold, pain and numbness in the affected limb, and the arteriogram confirmed that conventional surgical intervention could not be implemented. After the transplant, the pain in the lower limb improved significantly and the ulcer healed gradually without any transplant-related complications or adverse reactions, and the limb was finally successfully saved. Diabetic foot ulcers mostly occur after 10 years of diabetes, and the incidence of diabetic foot reaches 50% for those who have had the disease for more than 20 years. At present, there are more than 30 million diabetic patients in China, of which 10% to 50% will gradually develop diabetic foot, the incidence of foot gangrene is about 1.7%, while the incidence of gangrene in elderly diabetic patients over 60 years of age accounts for about 2.8% to 14.5%. However, diabetic foot is an incurable secondary disease of diabetes, and patients often face the tragic end of toe amputation, foot amputation or even amputation in the late stage. This technology uses the multi-differentiation potential and self-replication function of stem cells to transplant stem cells into ischemic limbs, which can differentiate and form neovascularization in the ischemic area of diabetic foot, thus improving the blood supply to the limb. Since the bone marrow stem cells for this cell therapy are taken from the patients themselves, the field is convenient and there is no immune rejection or ethical issues involved in embryonic stem cells.