With the advent of aging in China, diseases related to the elderly are becoming more and more common, among which delirium in old age is not uncommon in clinical practice, and there are difficulties in treating some patients, which is a popular topic of research in neurology psychiatry in recent years. The symptoms of geriatric delirium often fluctuate rapidly, even within a few minutes, and tend to worsen after sunset, often being relatively clear during the day, as in a normal person, and worsening at night when delirium cannot sleep. When consciousness is restored, the patient forgets all or part of the experience during the illness. The most striking symptom is clouded consciousness with disorientation to time, place, and people. It is difficult to concentrate. Disorganization of daily events and routine activities often occurs. Personality and mood changes are common. Symptoms include irritability, inappropriate behavior, timidity, excessive energy or even obvious signs of psychosis, and somatic irritability often manifested by constant walking back and forth. For a short period of time, the patient may exhibit conflicting emotions. The inability to organize thoughts, incoherent speech, and often significant slurring of speech place a great burden on family members to care for them and often make them miserable. Delirium in old age is often related to the following factors: 1. Central system disease factors: death, degenerative lesions or dysfunction of nerve cells in the brain, such as cerebral infarction, cerebral hemorrhage, traumatic brain injury, Alzheimer’s disease, alcoholic encephalopathy, etc. 2. Drug factors: diuretics, sedative-hypnotics, analgesics, antidepressants, antipsychotics and other drugs with antihistamine and anticholinergic effects, especially the irrational use of large doses can lead to delirium. The use of large doses can lead to delirium. 3, infectious disease factors: acute meningitis or encephalitis, or various infections outside the brain,. Pneumonia, urinary tract infection, sepsis or fever caused by viral infection in the vulnerable brain can cause 4, psychological factors: severe psychological trauma combined with brain damage caused by serious physical illness, is very easy to develop delirium. 5, other: such as sleep deprivation and sensory deprivation, can also cause delirium. Our department has accumulated a lot of experience in treating delirium in old age, which has enabled many patients to be cured and return to their families, reducing the burden of care on their families and improving their quality of life.