Condyloma acuminatum is caused by human papillomavirus, and humans are the only host of human papillomavirus (HPV). The HPV is classified into more than 100 subtypes using molecular biology techniques. The main viruses that cause warts are HPV-6, -11, -16, -18, etc. 90% of warts are caused by HPV-6 and HPV-11 infections. The incubation period of condyloma acuminatum is usually 1 to 8 months, with an average of 3 months. The most common sites are the external genitalia and the mucous membrane around the anus, the glans, coronal sulcus, prepuce, urethra, penis and perineum in men, the labia, vagina, clitoris, vagina, cervix, perineum and perineum in women, the anus and rectum in homosexuals, and occasionally the mouth, armpits, breasts, toes and other areas outside the anogenital area. The skin lesions start as single or multiple scattered reddish papules with soft texture and sharp tips, gradually increasing in size, which can be papular, papillate, cauliflower, coronary and myxoid; the warts are often white, pink or gray, with vesicles, oozing, maceration and rupture on the surface, which can be combined with bleeding and infection; most patients have no obvious conscious symptoms, but occasionally have foreign body sensation, burning pain, tingling or sexual intercourse. HPV infection is closely related to the occurrence of genital cancer. A few patients show latent infection or subclinical infection. It is believed that latent HPV infection (normal appearance of local skin mucosa and negative white acetate test, the presence of HPV can be detected by molecular biological methods) is one of the main reasons for recurrence of condyloma acuminata, while the presence and reactivation of subclinical infection (lesions that are not recognizable to the naked eye and positive white acetate test) is also an important factor for recurrence of the disease.