For primary tumors of the gallbladder, if it is an adenocarcinoma of the gallbladder, it is usually diagnosed by sending the gallbladder to the pathology department for pathological confirmation after surgery. For tumor diseases of the biliary system, the chances of recurrence and metastasis are high. Therefore, if the patient is found to have primary neoplastic disease of the gallbladder, such as intraoperative freezing, then radical surgery for gallbladder cancer should be actively considered, which generally requires a wedge-shaped resection of the gallbladder bed, that is, the fifth segment of the liver, followed by lymph node dissection of the hepatoduodenal ligament, followed by lymph node dissection of the pancreas, and biliary arteries and portal veins within the hepatoduodenal ligament. Skeletalization of the portal vein. With these radical treatments, the patient’s prognosis is generally better than that of simple cholecystectomy. In addition, the patient should undergo systemic intravenous chemotherapy and, if necessary, PET-CT of the whole body for metastases and recurrence of the disease.