Gastric adenocarcinoma can be cured if there are no distant metastases. The first choice is radical surgery to remove the entire tumor and part of the stomach or all of the stomach, reconstruction of the digestive tract, and removal of the perigastric lymph nodes, which is called radical surgery, followed by chemotherapy according to the pathology. In principle, chemotherapy may not be given after radical surgery for early gastric cancer. Usually, chemotherapy is given once a month for 4-6 times, and the cost of each hospitalization is about 10,000 RMB, including other radiotherapy, thermotherapy, immunotherapy, Chinese herbal medicine and biological therapy. For patients with advanced gastric adenocarcinoma with distant metastasis, palliative treatment is mainly used in the treatment. The so-called palliative treatment includes chemotherapy, targeted therapy, immunotherapy and symptomatic supportive therapy with the aim of long-term survival with tumor. Therefore, different treatment methods are suitable for different patients, which are closely related to the histological characteristics of gastric cancer, patient’s physical condition and tolerance level. The same treatment method often has different effects on different individuals, so different patients need to be considered and individualized. At the same time, we need to pay attention to alleviate patients’ pain, communicate with and encourage them more, so that they can reduce their mental burden and stay optimistic in spirit.