Biliary reflux gastritis has the potential to become cancerous, but the chances are small. Biliary reflux gastritis, also known as alkaline reflux gastritis, is mainly caused by pyloric lesions, such as dysfunction of the pyloric sphincter, or surgery on the pylorus of the stomach that results in the reflux of duodenal contents containing bile, pancreatic juice, etc. into the stomach. Since the stomach is acidic and bile is alkaline, bile reflux can lead to inflammation of the gastric mucosa, causing inflammation, erosion and even bleeding of the gastric mucosa and weakening the barrier function of the gastric mucosa, resulting in chronic lesions of the gastric mucosa. Common clinical manifestations include abdominal distension, heartburn, gastric bleeding, vomiting, etc. Long-term bile reflux gastritis may lead to esophagitis, gastric mucosal erosion, hyperplasia, active inflammation, gastric ulcer, and even promote the possibility of gastric cancer, but the chance of cancer is very low. Therefore, active treatment is needed for bile reflux gastritis, but there is no need to be overly nervous about its cancerous development.