The three scientists who won the first Nobel Prize in medicine and physiology in this century have confirmed after 50 years of dedicated research that neurotransmitter imbalance is the most fundamental cause of insomnia, anxiety and depression. Simply put, to completely eliminate insomnia, anxiety and depression at the same time, there must be two prerequisites: one is the two-way regulation of neurotransmitters, and the other is the absence of any toxic side effects.