I. The best time to conceive for women with hepatitis B. Normal liver function, low serum HBV DNA level, and no special changes in liver ultrasound. Therefore, if you plan to have a baby, it is recommended that you first go to the hospital for liver function, serum HBV DNA load, hepatitis B markers (commonly known as hepatitis B two-to-one), and liver ultrasound. If there are no protective antibodies, routine hepatitis B vaccination is recommended to prevent hepatitis B virus infection during pregnancy. The burden on the liver during pregnancy is very heavy. Some metabolic wastes from the fetus and a large amount of hormones produced by the placenta must be detoxified and processed by the pregnant woman’s liver before being excreted from the body. If the liver is severely damaged before pregnancy, it will be more detrimental to the liver during pregnancy, and heavy hepatitis or even liver failure may occur, which can seriously threaten the life of mother and child. Therefore, if the pre-pregnancy examination reveals abnormal liver function or cirrhosis, it is recommended to receive antiviral treatment problems before carefully considering childbirth. 48 weeks of treatment with interferon or long-acting interferon is recommended, because the interferon treatment course is more than definite and will not exceed 48 weeks. It is more appropriate to conceive six months after stopping the medication. One of the difficulties we have to face is that some women of childbearing age have a high hepatitis B viral load, normal liver function and normal liver ultrasound, and the infectious doctor says that they are in the immune tolerance period and there is no indication for treatment with drugs. In some cases, even after using antiviral drugs, the viral load does not come down, so what should I do? My advice is to conceive when it is time to conceive. The best age for a woman to have a baby is 25 years old and it is difficult to conceive beyond 35 years old. In the embryonic development and organ differentiation of early pregnancy, that is, within 12 weeks of gestation is still not advocated with antiviral drug therapy, after early pregnancy, the fetal organ differentiation is complete, with pregnancy B drugs is relatively safe, the drug available at this time is tenbivudine, tenofovir, can be taken until after delivery, according to the situation to decide the timing of discontinuation of drugs. If your husband has hepatitis B, if your condition requires antiviral treatment: (1) you can give antiviral treatment first, wait for a continuous treatment response, and then stop the medication for a period of time before conceiving; or conceive before antiviral treatment, and then carry out antiviral treatment; (2) for men who are receiving antiviral treatment, if you are using interferon drugs, you must stop the medication for more than 3 months before conceiving; if you are using nucleoside drugs, your condition is more severe. If you are using nucleoside analogues, you can stop the medication for more than 2 weeks and then conceive; if you cannot stop the medication in severe cases, you can switch to telbivudine or tenofovir for a period of time and then consider conceiving; (3) For men who conceive accidentally during oral nucleoside analogues, generally the woman can continue the pregnancy and observe closely; however, for men who conceive accidentally during interferon treatment, the safety is unknown and the woman is generally recommended to terminate the pregnancy. (2) If your liver function is normal and you do not have cirrhosis, you can conceive at any time; (3) If the husband is surface antigen or e antigen positive, regardless of whether the woman has hepatitis B, the child needs to be injected with high potency hepatitis B immunoglobulin + hepatitis B vaccine immediately after birth.