The causative factors of drug hepatitis can be considered from the following aspects: 1. Drug factors: The chemical composition of drugs includes active ingredients and non-active ingredients, and the excipients, additives and impurities in drugs may cause liver damage. Some herbal medicines may have a low content of active ingredients, while the content of non-active ingredients, i.e. impurities, is relatively high, so it is easy to cause liver damage. The dosage, frequency and duration of use of drugs are also important factors in causing drug-related hepatitis, so patients are advised to use drugs under the guidance of doctors. Drug hepatitis is related to drug interactions, some drugs alone may not cause liver damage, but several drugs together may cause liver damage; 2, individual factors: people have individual differences, some drugs may be safer for most people, but some people may be allergic or liver damage after using drugs. The choice of drug dosage is closely related to a person’s age, gender, weight, height, and body surface area.