Pancreatic tail occupation can be distinguished from benign and malignant by pathological examination, tumor markers and imaging examination. 1. Pathological examination: as a golden index to determine benign and malignant, the nature of the disease can be completely clarified. 2. Tumor markers: Typical malignant diseases in the tail of pancreas include pancreatic cancer, Ca-199 is a specific indicator of pancreatic cancer, which has a certain role in suggesting malignant tumors. 3. Imaging examination: good lesions have clear margins, intact envelope, uniform density, and generally do not invade the surrounding tissues; for malignant lesions, they have unclear borders, irregular growth, and peripheral invasion. Occupation of the tail of the pancreas need to improve the relevant examination, early diagnosis and early treatment, under the guidance of the doctor active treatment, to avoid deterioration of the situation.