Coughing in the middle of the night in an 8-month-old baby may be due to acute bronchitis, gastroesophageal reflux or infections such as whooping cough, etc., and should be treated according to the different causes. The common ones include anti-infection and symptomatic supportive treatment. 1. Acute bronchitis: due to the pathogen is mostly viral, generally do not use antibacterial drugs, mostly symptomatic supportive treatment, can be prescribed to be budesonide nebulized inhalation, oxygen and sputum inhalation and other symptomatic supportive treatment, usually should be sufficient rest, appropriate rehydration. 2. Gastroesophageal reflux: small babies due to the digestive tract development is not yet perfect, in the milk easy to occur after gastroesophageal reflux, you can be in the baby after eating milk for patting the back, appropriate elevation of the upper body, to reduce the gastroesophageal reflux, can help to alleviate the gastric acid reflux caused by the irritation of the cough. 3. Pertussis infection: 8-month-old babies with pertussis infection, prone to spasmodic cough at night, manifested as irritating wheezing cough, may be red or coughing and vomiting, and in severe cases may even have purple lips. Can be under the guidance of the doctor to be azithromycin anti-infective treatment, in addition to the need to be given budesonide, ambroxol and other anti-inflammatory phlegm, but also need to be treated with oxygen suction phlegm. If the 8-month-old baby coughing in the middle of the night, it is recommended to consult a doctor in a timely manner, in accordance with the doctor’s instructions for treatment, standardize the use of medication, so as not to delay the condition.