Into the twenty-first century, facial rejuvenation has become a new beauty trend, facial beauty into the anti-aging, rejuvenation, micropigmentation period, through the minimally invasive injection method, the injection material will be injected directly into the face, to play a rejuvenation to enhance the effectiveness of the beauty of the appearance. Injectable beauty has a long history, because of its low harm, natural effect, short recovery period, no surgery, no hospitalization, time-saving, less pain and immediate effect favored by the majority of cosmetic doctors and beauty seekers. However, cosmetic injections have also paid a very painful price, liquid paraffin, liquid silicone, polyacrylamide hydrogel and other injection materials have caused physical and even psychological harm to many patients. What kind of injectable materials are safe and effective products? Botulinum toxin (Botox): the main ingredient is highly purified botulinum toxin A. It acts on the endings of the nerves, which can relax the muscles and is used to treat active wrinkles caused by active muscle contraction. A very small amount of Botox injected precisely into specific facial muscles can effectively improve facial power wrinkles such as: crow’s feet at the corners of the eyes, wrinkles between the eyebrows, forehead wrinkles, fine lines under the eyes, wrinkles of the nose, etc., and can be a good way to improve the eyebrow sagging, facial drooping, sagging corners of the mouth and the neck wrinkles, also has a significant effect on the face due to biting muscle hypertrophy caused by the face of the broader. Thus, Botox injection can effectively eliminate the power expression lines in the upper face and enhance the lower face to create a delicate “V” shaped face. China SFDA approved the application of botulinum toxin for the United States Allergan production of Botox (Botox), and China’s Lanzhou Institute of Biological Products production of “Hengli” botulinum toxin, injections to maintain the effect of 6-8 months. Hyaluronic acid (hyaluronic acid): Hyaluronic acid exists in large quantities in the connective tissue of the human body and the dermis of the skin, which is full of water, is the skin’s moisturizing factor, and its moisturizing effect is 16 times that of collagen. As we age, the hyaluronic acid produced by the human body gradually decreases and the consumption of relative increase, so that the skin loses moisture and wrinkles are highlighted. Hyaluronic acid, because it originally exists in human skin, there is almost no allergic reaction after injection, and fused with the body’s original hyaluronic acid, the skin swells and fills up, wrinkles flatten and bulge, and the skin is young and firm. The indications of hyaluronic acid injection are filling, such as: forehead lines, lines between eyebrows, crow’s feet, nasolabial folds, tear troughs, and can also be used for chin augmentation, lip augmentation, nose job, earlobe augmentation, nose tip padding, cheek augmentation, etc., with extremely high safety. China’s SFDA approved the application of hyaluronic acid-based dermal filler produced by Swedish Q-Med, trade name Rylan, specification: Rylan 2, the effect lasts 6-12 months after injection. Collagen: It is highly purified human or animal collagen. Collagen is widely found in mammalian skin, bones, muscles and ligaments, and is the main connective tissue protein in animals. At present, the clinical application is more heterogeneous collagen biomaterials, made of injectable collagen solution, used for facial soft tissue filling plastic cosmetic, such as: facial depressed scar, soft tissue atrophy caused by trauma, aging wrinkles in specific parts of the face (e.g., forehead, between the eyebrows, perioral, eye corners, nasolabial folds, chin-lip grooves, etc.). China’s SFDA approved the use of Taiwan Shuangmei Bio-technology Co., Ltd. porcine collagen products “Shuangmei 1”. The effect lasts for 1-2 years after injection. Autologous fat injection and transplantation: Autologous fat injection and transplantation refers to a surgical method of sucking out the fat from the parts of the human body that are rich in fat, such as the abdomen, buttocks, thighs, etc., by liposuction, and then injecting and implanting them into the defective parts of the body that need to be changed after being processed into pure fat particles in order to perfect the shape of the defective parts. The biocompatibility of autologous fat is significantly better than that of artificial tissue substitutes, allogeneic or xenogenic collagen and other materials, and the absence of immune rejection is its greatest advantage. Autologous fat particle transplantation has a wide range of indications, such as for filling subcutaneous depressed defects or deformities in the face, improving soft tissue depressions in other parts of the body, breast augmentation with autologous fat, and reshaping and molding of genitals. With its unique advantages, autologous fat injection and grafting is now widely used in facial rejuvenation surgery, such as filling nasolabial folds, Sichuan lines, cheek augmentation, forehead, eyebrow arch, apple muscle. There is about 30-50% absorption rate after autologous fat injection and grafting, overcorrection and repeated injections are necessary.