Basophils are a type of white blood cell and normally account for no more than 1% of the total white blood cells in a routine blood test. If the blood test leukocytes are elevated, with basophils accounting for more than 10%-20% of the total leukocyte count, leukemia is suspected. If the patient has anemia manifestations such as pale lips and mouth, dry nails and yellow face at this time, and has recurrent infections and subcutaneous bleeding, it is recommended to actively improve relevant examinations and follow medical advice for treatment. If the routine blood test reveals a large number of elevated white blood cells and a large proportion of basophils, the doctor may recommend a bone marrow aspiration to obtain bone marrow tissue for observation under electron microscopy. Leukemia, considered as chronic granulocytic leukemia or basophilic leukemia. The two can also be differentiated based on tests. In chronic granulocytic leukemia, the entire granulocyte lineage is elevated and tests may reveal alkaline granulocytes accounting for more than 10% of the total leukocyte count, while in patients with basophilic leukemia, mainly alkaline granulocytes are elevated and alkaline granulocytes may account for more than 20% of the total leukocyte count in the blood. Basophilic leukemia can be divided into acute and chronic types, of which chronic basophilic leukemia and chronic granulocytic leukemia have similar clinical manifestations, both of which are characterized by anemia, bleeding, and recurrent infections, and both are basically treated with blood transfusions, along with immune drugs and targeted drugs. Chronic granulocytic leukemia can also be controlled with chemotherapy drugs, but chronic basophilic leukemia is less effective with chemotherapy and has a relatively poor prognosis. Patients with acute basophilic leukemia have an acute onset and are extremely rare clinically. In addition to anemia, bleeding, recurrent infections, allergic manifestations such as skin itching, edema, urticaria, etc., some patients also have vomiting, diarrhea, etc. Clinical treatment is limited and the prognosis is poor with a short survival period. It should be noted that the above is only a case of significant elevation of basophils, if only mildly elevated, high basophils may also be caused by chronic hemolysis, post-splenectomy complications, diabetes mellitus and many other diseases. It is also common to see various allergic diseases such as allergic enteritis and bronchial asthma, as well as diseases such as chickenpox and tuberculosis. Therefore, high basophilia is not the only basis for diagnosis, and patients should actively improve relevant tests to exclude relevant pathologies and not scare themselves.