Open fracture with exposed bone can be treated by debridement, fracture repositioning and fixation, soft tissue reconstruction and wound closure, and antibiotic application. 1. Wound debridement: the broken end of the fracture should be thoroughly debrided as early as possible. Repeatedly wash and disinfect the wound, remove foreign objects from the wound, excise completely necrotic tissues, and turn the contaminated wound into a relatively clean one. 2. Fracture reduction and fixation: the fracture end should be reduced first, and then according to the openness of the wound and the degree of contamination of the injury, the fracture part can be treated with external fixation bracket or internal fixation with steel plate. 3. Soft tissue reconstruction and wound closure: reduction incision suture, skin grafting at the wound, skin flap transplantation and other ways can be carried out, so that the soft tissues can be reconstructed and then the wound can be closed. 4. Application of antibiotics: antibiotics such as cefoperazone should be used as early as possible, and a skin test for β-lactam antibiotics should be performed before use. They can be used until 48 hours after wound closure to effectively prevent the formation of bacterial biofilm. It is recommended that patients seek timely medical attention, follow the doctor’s instructions for treatment, and do not blindly use medication and disposal.