In terms of general knowledge about the clinical manifestations of pancreatic cancer, there are many details that many people fail to grasp: 1. “Band-like” low back pain: From the existing knowledge, this symptom indicates that the tumor has invaded the retroperitoneal plexus, which is a manifestation of advanced tumor. In fact, any lesion that invades the retroperitoneal plexus may show similar performance. If this symptom appears for more than one year and the lesion does not increase significantly on imaging follow-up, it may be other lesions with slow growth and evolution (e.g., retroperitoneal fibrosis, inflammation, low-grade malignancy, etc.); if this symptom gradually worsens and the lesion gradually increases in extent on regular imaging follow-up, it may be a lesion with faster evolution (e.g., pancreatic cancer, pancreatitis that is not effectively controlled). pancreatitis). Extra-pancreatic metastases: The main extra-pancreatic metastases of pancreatic cancer are local lymph nodes and liver, once metastases occur, the prognosis is very poor and the survival time is not long. According to my experience, this is most likely to be metastasis from other tumors, so we should actively look for the primary focus and take targeted chemotherapy after taking pathology. If other medical history, clinical and laboratory tests do not suggest other tumors, PET-CT examination is a good choice. 3.Loss of appetite and weight loss: Literally speaking, it is too far-fetched to consider these two points as the manifestations of advanced pancreatic cancer. There are many reasons for loss of appetite. Only unexplained weight loss of more than 10% within 3 months should be noted in relation to pancreatic cancer. 4. Tumor growth rate: There are many types of pancreatic malignant tumors, and pancreatic ductal adenocarcinoma is one of the fastest growing tumors, if followed up at 3-month intervals, the tumor should increase significantly, while most benign lesions and low-grade malignant tumors grow much more slowly. In summary, the clinical manifestations of pancreatic cancer in the popular sense are too coarse and should not be too pessimistic. We should establish confidence in overcoming the disease, find out the suspicions and take targeted measures in close follow-up and careful analysis.