The second recurrence of tongue cancer is generally more serious, and patients are advised to take appropriate treatments, such as surgical treatment, radiotherapy and chemotherapy, in time under doctors’ guidance. Tongue cancer is a malignant tumor that occurs in the tongue of oral cavity and its recurrence rate is high. It is difficult to treat the second recurrence of tongue cancer, and patients are mostly accompanied by poor physical condition, neck lymph nodes or distant metastasis, which have different degrees of impact on patients’ prognosis and quality of life. If the physical condition is better and the treatment effect is also good, the survival period may be better and the quality of survival is guaranteed. Otherwise, the survival period is unsatisfactory and the quality of life is seriously affected. When tongue cancer patients have a second recurrence, they can choose surgical treatment, such as tracheotomy, prophylactic neck clearance, reconstruction, etc., taking into account their own conditions. At the same time, they can cooperate with radiotherapy and chemotherapy, so as to achieve the effect of improving prognosis and survival quality. It is suggested that tongue cancer patients should go to regular hospitals in time for consultation, standardized treatment and review under doctors’ guidance.