Chemotherapy is a very effective treatment for lung cancer, so what conditions of lung cancer require chemotherapy? What are the considerations of chemotherapy? What are the chemotherapy regimens for lung cancer?
Chemotherapy for lung cancer, short for chemotherapy for lung cancer, is a treatment method that uses chemical drugs to stop the proliferation, infiltration and metastasis of lung cancer cells until the cancer cells are finally killed. It is a systemic treatment, and together with surgery and radiotherapy, it is known as the 3 major treatments for cancer.
Under what circumstances does lung cancer need chemotherapy?
1.Stage I to IIIA non-small cell lung cancer (NSCLC) is mainly treated by surgery, and chemotherapy is generally used as postoperative adjuvant treatment, and also as preoperative neoadjuvant chemotherapy for stage IIIA patients.
Stage 2 and V patients are mainly treated with chemotherapy, and local palliative radiotherapy can be administered. Although there are many effective chemotherapy regimens for non-small cell lung cancer (NSCLC), the overall efficacy is not as good as that for small cell lung cancer (SCLC). The efficacy rate is generally 20% to 40%, and there are reports that increasing the dose can increase the intensity DN to about 50%, but most of them need hematopoietic stimulating factor treatment.
3. Few patients with non-small cell lung cancer (NSCLC) can achieve complete remission with chemotherapy, so most cannot achieve radical cure with chemotherapy. Other treatments such as surgery or radiotherapy are needed.
4.Small cell lung cancer (SCLC) can improve survival through combination of radiotherapy, chemotherapy and surgery in the limited stage, while chemotherapy is the main treatment in the extensive stage, and the prognosis is very poor.
The interval between courses of chemotherapy for lung cancer precautions.
Since the toxic effects of existing drugs can often continue for several weeks after discontinuation, each week should be spaced at intervals of 4-6 weeks from the date of starting chemotherapy, but the toxic effects of the drugs must disappear before the next course of treatment is used. Special attention should be paid to the discontinuation or change of drugs in the course of chemotherapy.
At present, chemotherapy for lung cancer generally cannot achieve radical cure, therefore, at certain stage of chemotherapy, it should be combined with surgery or radiation therapy when possible to enhance local or regional control of tumor. The number of courses should be increased according to the patient’s response and efficacy, and complete remission should be achieved as much as possible.
Chemotherapy regimens for SCLC and NSCLC
The first-line regimen for SCLC is EP and CE, EP is Vp16 (cisplatin) + PDD (cisplatin), or CBP (carboplatin) + Vp16 (cisplatin); the second-line regimen is Topotecan (Hormexin) or Irinotecan (Kepto).
2, NSCLC commonly used regimen first-line standard regimen is generally three: vincristine (Noviben) + cisplatin or carboplatin, paclitaxel (Tysol) + cisplatin or carboplatin, gemcitabine (Kinzel) + cisplatin or carboplatin. The efficacy is comparable and not significantly different, but there are differences in toxicities.
Second-line standard regimens are currently used clinically in two.
1. doxorubicin and lipitor. From the clinical trials and applications, doxorubicin has been used for many years, the efficacy is certain, is the classic standard second-line program, but the toxic side effects are large.
2.Libetide, which has just been marketed for more than two years, has been clinically proven to have good efficacy, and after pretreatment, the toxic side effects are minimal and well tolerated by patients.
3.Other regimens available for non-small cell lung cancer include irinotecan (Kepto), epi-amycin, mitomycin, etc.
4. Combined with Chinese medicine, chemotherapy has strong toxic side effects and is likely to cause various uncomfortable symptoms during chemotherapy administration. Therefore, during chemotherapy for lung cancer, it can also be combined with TCM treatment to enhance the therapeutic effect, reduce the side effects of chemotherapy, suppress tumor and eliminate tumor, so as to achieve better therapeutic effect. For example, ganoderma lucidum (high concentration ganoderma lucidum preparation, medical grade ganoderma lucidum spore powder, etc.) has excellent anti-chemotherapy effect.
Complete list of chemotherapy regimens for lung cancer
1.CAP regimen.
2.CAV regimen.
3.CE chemotherapy regimen.
4.NC chemotherapy regimen 5.PC chemotherapy regimen.
6.PI regimen.
7.TP chemotherapy regimen.
8.Docetaxel chemotherapy regimen.
9.Kenzyme and cisplatin chemotherapy regimens.
10.Pemetrexed chemotherapy regimen.
11.Gicitabine single agent chemotherapy regimen.